Val Watts doggedly hunts an undruggable enzyme as target for chronic pain treatment

Val Watts enjoys a tricky puzzle. The associate dean for research and professor of medicinal chemistry and molecular pharmacology built his career attempting to find solutions to problems others have deemed unsolvable. 

His latest white whale is a doozy. Watts wants to develop pain medications as strong and effective as opioids, without their addictive properties. To do so, he’s collaborating with other College of Pharmacy researchers to target the adenylyl cyclase enzyme, a signal pathway shared by opioid receptors and dopamine receptors.

Greg Baker leads AffirmedRx, a pharmacy benefit manager and public benefit corporation that’s shaking up the traditional pharmaceutical supply chain

Greg Baker is angry. He thinks you should be angry, too. 

He’s on a crusade to reform traditional pharmacy benefit managers (PBMs), the companies that manage prescription drug benefits on behalf of health insurers. In May 2023, Baker testified before the U.S. House Committee on Oversight and Accountability that a handful of large PBMs control up to 80% of the market, to the detriment of the American public.

Center for Health Excellence, Quality and Innovation launches Nutrition Hub at IU Health Methodist Hospital in Indy

Sufficient access to high-quality, nutritious food is necessary for overall health, but nearly 13% of U.S. households face food insecurity. A new initiative launched by the Center for Health Excellence, Quality and Innovation (CHEQI) in the College of Pharmacy aims to integrate nutrition and health care, raising awareness for the concept of food as medicine and providing patients with nutritious food tailored to their individual medical needs. 

The Nutrition Hub, which opened at IU Health Methodist Hospital in Indianapolis in November 2023, is a partnership between CHEQI, the American Heart Association and Gleaners Food Bank of Indiana, the largest hunger relief organization in the state.

R’Kes Starling leverages technology to expand access to clinical trials for underrepresented populations 

It all started with his mother. That’s how R’Kes Starling (BS ’02) attributes his inspiration for founding Reveles, an AI-powered patient engagement company that partners with drug sponsors and research institutions to increase awareness and expand clinical trial access to underrepresented patients. By prioritizing diversity within studies, Reveles helps to ensure marginalized communities do not miss out on life-changing care while simultaneously advancing a more equitable approach to health care. 

Oldest and largest program in the country leverages industry partnerships to advance radiopharmaceutical training in Indianapolis

In 1946, nearly 50 years after the Polish physicist and chemist Marie Curie coined the term radioactivity, Purdue University received the first shipment of radioactive materials for use in the development of medical therapy from Oak Ridge National Laboratory in Tennessee.

John E. Christian (BS ’39, PhD HHS ’44), a professor of pharmaceutical chemistry, was conducting pioneering research in the emerging field of bionucleonics, a term that reportedly originated from then Purdue President Frederick Hovde to describe the biological application of nuclear physics. At the time, Christian was one of a handful of people in the country accomplishing meaningful work in peaceful uses of radioactive materials. 

The first Black woman to earn a DVM degree at Purdue University, Dr. Doris Hughes-Moore, attributes her success to the sacrifices made by her ancestors

Dr. Doris Hughes-Moore (DVM ’73) recognizes the importance of preserving and honoring history. She’s president of the board for the Wilson Bruce Evans Home Historical Society, an organization with a mission to preserve the home and promote its historical significance as part of Black American history and culture in Oberlin, Ohio. She’s also the great-great granddaughter of Wilson Bruce Evans and his wife, Sarah Jane Evans.

Identification of nuclear protein’s critical role in cell degradation could lead to prevention or even reversal of age-related diseases

Tantalizing legends of a fountain of youth spurred explorers to navigate the globe for millennia in search of the restorative waters that promised to wind back the hands of time and halt the process of aging. Recent research conducted in the Purdue University College of Veterinary Medicine and the Bindley Bioscience Center reveals the real secret lies not in myth, but in science.

As we age, our cells undergo senescence, a process where they cease dividing and enter a state of permanent growth arrest without dying off. Senescence is actually a good thing, because if cells continue to divide uncontrollably, they become tumorigenic or cancer-initiating cells. It’s when too many senescent cells build up that they cause problems.

Alumnus honors late wife by funding research for swallowing disorders

Dave Greulich (ME’67) never realized he believed in love at first sight until he met Dee.

A friend fixed the couple up on a blind date in their hometown of Louisville, Kentucky, a few weeks before Greulich left for his freshman year at Purdue. Deanna Schneider was an aspiring nurse with a gentle disposition who exhibited great empathy and care for others. Greulich was smitten. The pair continued to date while attending separate colleges and married on January 27, 1968.  

An insider’s look at a university collection so valuable, the professor who built it once stole it back.

The earliest herbarium—a collection of plant samples preserved for scientific study—dates to 16th-century Italy, when the Bologna physician and botanist Luca Ghini (1490–1556) sought to make plant material available to his students in winter when the plants were dead or dormant.

The specimens were flattened between two pieces of paper to remove moisture. Once dried, they were mounted on paper sheets with notations on the plant’s name, where the plant was gathered, and any distinctive features. The pages were bound into volumes to enable transport from one location to another, thus making plant material from faraway places available indefinitely.

Savoie research team builds largest dataset of reaction mechanisms in existence

Theoreticians have worked in tandem with experimentalists since the dawn of the scientific age. The advent of machine learning facilitated computational work on a larger scale and a faster timetable. While data about the properties of specific molecules has been available for years, predications of how those molecules would react in different environments and under various conditions remained elusive.

After developing the automated computational method YARP — Yet Another Reaction Program — two years ago, a research team led by Brett Savoie, the Charles Davidson Associate Professor of Chemical Engineering, applied YARP’s technology to build the largest dataset of reaction mechanisms in existence.

Meet students from the talented men’s practice team who help prepare Women’s basketball to face their toughest competition.

When Matt Collins drives to the basket and sinks a layup in Mackey Arena, he hears the thunderous roar of the crowd echoing across the rafters.

Often cited as the loudest arena in the Big Ten, nothing pumps a player up like the electric atmosphere created by 10,000-plus screaming fans on their feet. If it was a particularly challenging play, Collins might even throw a little celebration in to stoke the competitive juices of the opposing team.

Oak Ridge National Laboratory’s Jeremy Busby’ 95 Developed Meticulous Mentality in K-States Nuclear Engineering Program.

On a bookshelf in Jeremy Busby’s office, tucked among scientific journals, policy manuals and bric-a-brac accumulated during his nearly 30 years as a nuclear engineer, sits his undergraduate notebook from Applied Reactors Theory I & II. Busby ’95 is now the associate lab director for the isotope science and engineering directorate at Oak Ridge National Laboratory, a federally funded research and development center in Oak Ridge, Tennessee. He took those courses with Professor Ken Shultis and Professor Richard Faw in 1992 and 1993, but the principles instilled have stayed with him throughout his distinguished career.

Promising initial research could lead to more effective seasonal flu shots and ward against future pandemics

Dry cough. Runny nose. Sore throat. Muscle aches. These symptoms are all familiar to anyone who’s contracted the common flu, a respiratory illness that affects one billion people each year. The Centers for Disease Control and Prevention recommend most people receive yearly flu shots because the seasonal influenza virus mutates constantly, creating new strains that circulate from person-to-person leading to seasonal flu epidemics. These yearly vaccines are formulated to protect against the specific virus strains expected to spread and cause illness during that flu season, typically October through May.

The Stewarts at Westwood

Robert Bruce Stewart (HDR M’68), known as R.B., joined the Purdue University staff as controller in 1925. At that time, Purdue enrolled 3,000 students, the physical plant was worth $3 million, and the endowment totaled $340,000.

Stewart, who went on to become the university’s first vice president and treasurer, is credited by many with influencing the character and growth of Purdue University. He spent 36 years building the university both fiscally and physically.

New genetic testing available through ADDL will help dog breeders eliminate specific diseases

Research findings by genetic scientists in the Purdue University College of Veterinary Medicine have the power to eradicate specific genetic diseases within certain dog breeds. Testing for the genetic mutations will be offered by the Animal Disease Diagnostic Laboratory (ADDL) at Purdue. As the first such tests offered to the general public for three new canine genetic diseases, these screenings will enable breeders to identify which dogs are carriers for a disease and could possibly pass it on to offspring. By ensuring two carriers are not bred together, the disease can be halted before it spreads throughout the breed.

Geochemist Marissa Tremblay ’12 analyzes Antarctic rocks to unravel Earth’s climate chronology and predict the planet’s future environment

A geologic field excursion to Death Valley during spring break her first year at Barnard set Marissa Tremblay ’12 on course to becoming a scientist. She entered college intending to pursue a law degree, but stepping foot on that vast, desolate desert landscape marked with sand dunes ignited a curiosity to uncover the stories in stones.

Treatment in development by Adipo Therapeutics holds promise for millions who struggle with weight loss and blood glucose control

Eat less. Exercise more. It sounds so simple. But if it were that simple, America wouldn’t be facing the dual epidemics of obesity and diabetes.

Adipo Therapeutics, a Purdue Research Foundation-backed startup, is developing a unique treatment approach that turns bad fat into good fat. This disruptive nanotherapeutic delivery could provide a safe and effective way to treat obesity and Type 2 diabetes.

Longtime diplomat and educator Patrick Mendis retains strong ties to Minnesota.

With humility and gratitude, Patrick Mendis (M.A. ’86, Ph.D. ’89) has embraced adventure, defied a prophecy, and charted his own course through life. 

Mendis says a horoscope reading when he was an infant said he wouldn’t live past his first birthday. His mother, a Sinhalese Buddhist traditionalist, heeded the scholarly monk’s warning to raise her son outside the home, sending him to live with his Catholic paternal grandparents in rural Sri Lanka when he was 7 months old. His grandparents told him he was adopted, and that they found him under a banyan tree.

Enhancing Well-being and Boosting Productivity in Dairy Cows

Indiana is home to more than 800 dairy farms, generating an average of nearly $700 million in direct farm income annually, according to the Indiana State Department of Agriculture. The average dairy cow produces around 2,320 gallons of milk per year, but metabolic disorders can affect that output as well as animal well-being.

Purdue University Cytometry Laboratories Aim to Develop Portable Toxin and Pathogen Detection Device

An estimated 48 million people in the United States experience foodborne illness each year, according to the Centers for Disease Control and Prevention. Of those, 128,000 cases require hospitalization and 3,000 result in death. A 2010 report published by the Produce Safety Project estimated that foodborne illnesses cost $152 billion in medical expenses, lost productivity and business, lawsuits and compromised branding.

Donation of House Honors Al Altschaeffl, who Contributed to Many Iconic Campus Structures

What do Mackey Arena, Neil Armstrong Hall of Engineering, the Bell Tower and the Gateway to the Future arch have in common? They are among the more than 170 building projects across campus with soil foundations designed by Al Altschaeffl (BSCE 1952, MSCE 1955 PhD 1960), a professor of civil engineer-ing with expertise in geotechnical engineering who continued to consult on projects following his retirement from the University in 2000.

First-of-its-kind Vector-borne Disease Panel Screens for 22 Different Pathogens in a Single Test

A diagnostic panel developed by researchers in the Purdue University College of Veterinary Medicine will enable its Animal Disease Diagnostic Laboratory (ADDL) to screen for 22 different vector-borne pathogens in a single test. The panel, designed to be used on cats and dogs, is the only test of its kind and now is available to clients of the ADDL.

Silver Star recipient Antonio Gonzalez ’94 placed his trust in faith, football 

Children growing up in the predominantly Mexican-American neighborhood of Boyle Heights in East Los Angeles in the 1980s and ’90s lived on the razor’s edge between childhood innocence and gang violence.

Plagued by high violent crime rates, struggling public schools and poverty, those who yearned to escape the concrete jungle of Boyle Heights saw two options — go to college or enlist in the military. In time, Army Sgt. Maj. Antonio Gonzalez ’94 would do both, earning a football scholarship to Kansas State University and receiving a Silver Star Medal recognizing his gallantry in action.

New methodology may one day map forests around the world

What if we could map every tree on the planet?

It’s a question that drives the work of Joshua Carpenter (MS’20), a PhD student and researcher in the Geospatial Data Science Lab supervised by Jinha Jung, Assistant Professor of Civil Engineering.

Just as the field of precision agriculture uses high technology sensor and analysis tools to measure the growth and health of fields of crops, Carpenter is developing methodologies that could one day be similarly applied to forests around the globe.

MATC launches bilingual welding program

Karen Feliciano says people are often surprised to learn she is a welder because “I don’t look like a typical welder to them. It’s very much a male-dominated field.”

Yet the MATC welding instructor sees herself in her students every day.

“My students inspire me,” Feliciano said. “I see the challenges I faced when I moved to Wisconsin from Puerto Rico. I see how much I struggled when I was first starting out in this career. But I see myself in their successes, too.”

Mopping produces pollutants similar to vehicle emissions

The fresh-scented products used to clean our homes and offices come with risks to our respira-tory health. The chemicals used to create scents such as lemon and pine pollute indoor air with nano-sized particles in similar ways that motor emissions affect the air we breathe outdoors, according to a new study published in the journal Science Advances.

Physics equations drive optimization of complex engineered systems

Computational models allow researchers to analyze and design complex systems, but development can be a slow process. Leifur Leifsson, associate professor and principal investigator of the Computational Design Lab, uses physics equations to optimize engineered systems for aircraft and space systems as well as microwave systems, nondestructive testing systems and food-water-energy systems.

Rear admiral Peg Klein anchors virtue and ethics at the center of decision-making

Raised near Naval Air Station South Weymouth outside of Boston, MA, Rear Admiral Peg Klein ’81, USN (Ret.), developed a passion for aviation at an early age. Her father, a professor of aviation science and a Navy reservist, frequently took Klein flying. 

“I remember when my dad got his private pilot’s license,” Klein said. “I would look over his shoulder while he was studying for ground school. I waited for him at the airfield while he took flight lessons. The first time he flew me over Cape Cod, it was thrilling. I loved being in the air. I loved what you could see from the air.”