Val Watts doggedly hunts an undruggable enzyme as target for chronic pain treatment
Val Watts enjoys a tricky puzzle. The associate dean for research and professor of medicinal chemistry and molecular pharmacology built his career attempting to find solutions to problems others have deemed unsolvable.
His latest white whale is a doozy. Watts wants to develop pain medications as strong and effective as opioids, without their addictive properties. To do so, he’s collaborating with other College of Pharmacy researchers to target the adenylyl cyclase enzyme, a signal pathway shared by opioid receptors and dopamine receptors.
Center for Health Excellence, Quality and Innovation launches Nutrition Hub at IU Health Methodist Hospital in Indy
Sufficient access to high-quality, nutritious food is necessary for overall health, but nearly 13% of U.S. households face food insecurity. A new initiative launched by the Center for Health Excellence, Quality and Innovation (CHEQI) in the College of Pharmacy aims to integrate nutrition and health care, raising awareness for the concept of food as medicine and providing patients with nutritious food tailored to their individual medical needs.
The Nutrition Hub, which opened at IU Health Methodist Hospital in Indianapolis in November 2023, is a partnership between CHEQI, the American Heart Association and Gleaners Food Bank of Indiana, the largest hunger relief organization in the state.
R’Kes Starling leverages technology to expand access to clinical trials for underrepresented populations
It all started with his mother. That’s how R’Kes Starling (BS ’02) attributes his inspiration for founding Reveles, an AI-powered patient engagement company that partners with drug sponsors and research institutions to increase awareness and expand clinical trial access to underrepresented patients. By prioritizing diversity within studies, Reveles helps to ensure marginalized communities do not miss out on life-changing care while simultaneously advancing a more equitable approach to health care.
Oldest and largest program in the country leverages industry partnerships to advance radiopharmaceutical training in Indianapolis
In 1946, nearly 50 years after the Polish physicist and chemist Marie Curie coined the term radioactivity, Purdue University received the first shipment of radioactive materials for use in the development of medical therapy from Oak Ridge National Laboratory in Tennessee.
John E. Christian (BS ’39, PhD HHS ’44), a professor of pharmaceutical chemistry, was conducting pioneering research in the emerging field of bionucleonics, a term that reportedly originated from then Purdue President Frederick Hovde to describe the biological application of nuclear physics. At the time, Christian was one of a handful of people in the country accomplishing meaningful work in peaceful uses of radioactive materials.
Identification of nuclear protein’s critical role in cell degradation could lead to prevention or even reversal of age-related diseases
Tantalizing legends of a fountain of youth spurred explorers to navigate the globe for millennia in search of the restorative waters that promised to wind back the hands of time and halt the process of aging. Recent research conducted in the Purdue University College of Veterinary Medicine and the Bindley Bioscience Center reveals the real secret lies not in myth, but in science.
As we age, our cells undergo senescence, a process where they cease dividing and enter a state of permanent growth arrest without dying off. Senescence is actually a good thing, because if cells continue to divide uncontrollably, they become tumorigenic or cancer-initiating cells. It’s when too many senescent cells build up that they cause problems.
Alumnus honors late wife by funding research for swallowing disorders
Dave Greulich (ME’67) never realized he believed in love at first sight until he met Dee.
A friend fixed the couple up on a blind date in their hometown of Louisville, Kentucky, a few weeks before Greulich left for his freshman year at Purdue. Deanna Schneider was an aspiring nurse with a gentle disposition who exhibited great empathy and care for others. Greulich was smitten. The pair continued to date while attending separate colleges and married on January 27, 1968.
Savoie research team builds largest dataset of reaction mechanisms in existence
Theoreticians have worked in tandem with experimentalists since the dawn of the scientific age. The advent of machine learning facilitated computational work on a larger scale and a faster timetable. While data about the properties of specific molecules has been available for years, predications of how those molecules would react in different environments and under various conditions remained elusive.
After developing the automated computational method YARP — Yet Another Reaction Program — two years ago, a research team led by Brett Savoie, the Charles Davidson Associate Professor of Chemical Engineering, applied YARP’s technology to build the largest dataset of reaction mechanisms in existence.
Promising initial research could lead to more effective seasonal flu shots and ward against future pandemics
Dry cough. Runny nose. Sore throat. Muscle aches. These symptoms are all familiar to anyone who’s contracted the common flu, a respiratory illness that affects one billion people each year. The Centers for Disease Control and Prevention recommend most people receive yearly flu shots because the seasonal influenza virus mutates constantly, creating new strains that circulate from person-to-person leading to seasonal flu epidemics. These yearly vaccines are formulated to protect against the specific virus strains expected to spread and cause illness during that flu season, typically October through May.
New genetic testing available through ADDL will help dog breeders eliminate specific diseases
Research findings by genetic scientists in the Purdue University College of Veterinary Medicine have the power to eradicate specific genetic diseases within certain dog breeds. Testing for the genetic mutations will be offered by the Animal Disease Diagnostic Laboratory (ADDL) at Purdue. As the first such tests offered to the general public for three new canine genetic diseases, these screenings will enable breeders to identify which dogs are carriers for a disease and could possibly pass it on to offspring. By ensuring two carriers are not bred together, the disease can be halted before it spreads throughout the breed.
Treatment in development by Adipo Therapeutics holds promise for millions who struggle with weight loss and blood glucose control
Eat less. Exercise more. It sounds so simple. But if it were that simple, America wouldn’t be facing the dual epidemics of obesity and diabetes.
Adipo Therapeutics, a Purdue Research Foundation-backed startup, is developing a unique treatment approach that turns bad fat into good fat. This disruptive nanotherapeutic delivery could provide a safe and effective way to treat obesity and Type 2 diabetes.
Enhancing Well-being and Boosting Productivity in Dairy Cows
Indiana is home to more than 800 dairy farms, generating an average of nearly $700 million in direct farm income annually, according to the Indiana State Department of Agriculture. The average dairy cow produces around 2,320 gallons of milk per year, but metabolic disorders can affect that output as well as animal well-being.
Purdue University Cytometry Laboratories Aim to Develop Portable Toxin and Pathogen Detection Device
An estimated 48 million people in the United States experience foodborne illness each year, according to the Centers for Disease Control and Prevention. Of those, 128,000 cases require hospitalization and 3,000 result in death. A 2010 report published by the Produce Safety Project estimated that foodborne illnesses cost $152 billion in medical expenses, lost productivity and business, lawsuits and compromised branding.
Donation of House Honors Al Altschaeffl, who Contributed to Many Iconic Campus Structures
What do Mackey Arena, Neil Armstrong Hall of Engineering, the Bell Tower and the Gateway to the Future arch have in common? They are among the more than 170 building projects across campus with soil foundations designed by Al Altschaeffl (BSCE 1952, MSCE 1955 PhD 1960), a professor of civil engineer-ing with expertise in geotechnical engineering who continued to consult on projects following his retirement from the University in 2000.
First-of-its-kind Vector-borne Disease Panel Screens for 22 Different Pathogens in a Single Test
A diagnostic panel developed by researchers in the Purdue University College of Veterinary Medicine will enable its Animal Disease Diagnostic Laboratory (ADDL) to screen for 22 different vector-borne pathogens in a single test. The panel, designed to be used on cats and dogs, is the only test of its kind and now is available to clients of the ADDL.
New methodology may one day map forests around the world
What if we could map every tree on the planet?
It’s a question that drives the work of Joshua Carpenter (MS’20), a PhD student and researcher in the Geospatial Data Science Lab supervised by Jinha Jung, Assistant Professor of Civil Engineering.
Just as the field of precision agriculture uses high technology sensor and analysis tools to measure the growth and health of fields of crops, Carpenter is developing methodologies that could one day be similarly applied to forests around the globe.
Mopping produces pollutants similar to vehicle emissions
The fresh-scented products used to clean our homes and offices come with risks to our respira-tory health. The chemicals used to create scents such as lemon and pine pollute indoor air with nano-sized particles in similar ways that motor emissions affect the air we breathe outdoors, according to a new study published in the journal Science Advances.
Mediavine co-founders credit collaboration and transparency for company’s rise to internet giant.
When Matt Richenthal ’02 resigned from his role as a writer for a Boston start-up to launch his own content company called iScribe — “a terrible, awful name” — in 2004, he had no idea the business would one day grow into Mediavine, one of “The 20 Internet Giants That Rule the Web” as declared by Visual Capitalist in January. He only knew he wanted Steve Marsi ’01 along for the ride.
Could Hydrogen Hold the Solution to Sustainable Jet Fuel?
As more countries around the world commit to net-zero carbon emissions by 2050, industry groups are following suit. Among them, the members of the International Air Transport Association who announced a commitment to take action to cut emissions among global airlines in October.
Caesars Entertainment Equine Specialty Hospital Second Facility in the Country to Install Large Gantry CT Machine
The Caesars Entertainment Equine Specialty Hospital, a satellite facility of the Purdue University College of Veterinary Medicine, is among the first veterinary hospitals in the nation to install a specialized large gantry helical CT scanning machine. The device, manufactured by Qalibra, is adapted to the anatomy and behavior of equine patients and provides more advanced diagnostic capabilities for medical staff treating equine athletes by covering more anatomy with greater accuracy.
Mighty backpack captures millions of topographical data points in minutes
Surveyors have been measuring and documenting the topography of the Earth for thousands of years. Though the instruments have evolved from the early days of rope stretchers to modern total stations, it’s been challenging to collect accurate data efficiently when surveying heavily wooded areas, until now. A team of Purdue researchers is revolutionizing traditional ground surveying methods with a new technology that maps millions of elevation points in mere minutes simply by walking around the area wearing a backpack.
Could Hydrogen Hold the Solution to Sustainable Jet Fuel?
As more countries around the world commit to net-zero carbon emissions by 2050, industry groups are following suit. Among them, the members of the International Air Transport Association who announced a commitment to take action to cut emissions among global airlines in October.
NASA-funded project aims to develop guidance system for manned mission to the Red Planet
After the Perseverance rover successfully touched down on Mars in February 2021 following a landing sequence scientists refer to as “seven minutes of terror,” the NASA mission was widely celebrated. It wasn’t just that Perseverance is the largest, most advanced rover NASA has ever sent to another world. It’s that landing on Mars is extremely difficult.
Computational prototyping of rotor blades speeds design of more agile, efficient ‘flying cars’
Flying cars have long been popularized as the transportation mode of the future. Thanks to technology licensed in part through Purdue University, the future of flying cars may be closer than we think.
A U-M connection led to an altruistic organ donation, despite COVID-19 and a cancer scare.
For years, Ed Silberman lived a relatively normal life during the day. But every night, the 63-year-old financial adviser from Cherry Hill, New Jersey, went through two rounds of peritoneal dialysis, which uses the abdominal lining to filter blood inside the body. At his age, a normal kidney functions at 85% or higher. By fall 2019, Silberman’s kidneys were functioning at 7%.
As one of 100,000 people waiting for a kidney transplant, his best hope was to match with a living donor. So Silberman’s family, including son-in-law Jeremy Garson, JD’14, launched a social media campaign to find a stranger to save Silberman’s life.
High capacity batteries key to evolving autonomous systems
Cloud computing supports a vast array of information and systems every day. Whether it’s Google, social media or file storage, billions of people rely on the internet to stay connected. When that connection is interrupted, it causes inconvenience for the average user. However, if autonomous systems were to rely solely on cloud computing, maintaining a connection could mean the difference between safe operation and disaster. Imagine a self-driving car that required a stable cellular connection to avoid collision.
Remains of soldier killed in Vietnam return to Indiana after 51 years
Ann (Bardach) Vollmar (LA’67) will never forget the cold January day in 1968 when an army captain from Fort Harrison knocked on the door of her family’s Westfield, Indiana, home. Her father was away in New York City for business, and her mother was still at work in downtown Indianapolis. Vollmar was home alone with her younger brother, and the two of them knew the captain’s visit must be related to their oldest brother, 1st Lt. Alan Bardach (M’66), who was fighting in Vietnam.
Alumnae share their roads to success at KAR
Robin Leslie (T’84) doesn’t think of herself as a trailblazer. But when she enrolled in computer information technology at Purdue, the department was in its infancy. She was one of few women in the major — and one of few students of color.
“It was a new field,” Leslie says. “Not very many people looked like me. I just focused on my work and what I needed to learn. I knew I wanted to work in information technology (IT) for the rest of my life.”
Houston Boilers rally to aid family recovering from Hurricane Harvey
Steve and Cathy Gurnell were prepared to wait it out. They’d lived in their home in Katy, Texas, a western suburb of Houston, for 19 years. No strangers to bad storms, they’d stayed through Rita (2005), Ike (2008), and other smaller hurricanes and tropical storms. As rain from Hurricane Harvey pummeled Texas, friends and family called and texted the Gurnells to check on their safety. Among those concerned were the couple’s middle child, Carrie (LA’10), an assistant volleyball coach at Gardner-Webb University in Boiling Springs, North Carolina.
Cary A unit friends celebrate 45th annual reunion
Ask any Cary Quad resident circa 1974, “Who was the biggest jerk who walked the halls?” and you were likely to hear the same answer: Chuck Harville (P’76, DP’89). It was a mantle he didn’t mind. It can be fun to be the instigator. In those days, orientation programs were less structured, and as leader of A unit orientation, it fell to Harville to assimilate the frosh.
Telescoping prosthesis enables 10-year-old girl to bow violin
It’s atypical to see a piano as part of a grade school orchestra ensemble, but that’s exactly what Zayra Vincent encountered when she visited the Burgin Elementary School music room this spring. There, in the back of the Arlignton, Texas, classroom, a smiling 10-year-old girl plucked out notes on the keyboard with one finger.