Science

In Pursuit of a Non-Opioid Analgesic

In Pursuit of a Non-Opioid Analgesic

Val Watts doggedly hunts an undruggable enzyme as target for chronic pain treatment

Val Watts enjoys a tricky puzzle. The associate dean for research and professor of medicinal chemistry and molecular pharmacology built his career attempting to find solutions to problems others have deemed unsolvable. 

His latest white whale is a doozy. Watts wants to develop pain medications as strong and effective as opioids, without their addictive properties. To do so, he’s collaborating with other College of Pharmacy researchers to target the adenylyl cyclase enzyme, a signal pathway shared by opioid receptors and dopamine receptors.

Purdue Nuclear Pharmacy

Purdue Nuclear Pharmacy

Oldest and largest program in the country leverages industry partnerships to advance radiopharmaceutical training in Indianapolis

In 1946, nearly 50 years after the Polish physicist and chemist Marie Curie coined the term radioactivity, Purdue University received the first shipment of radioactive materials for use in the development of medical therapy from Oak Ridge National Laboratory in Tennessee.

John E. Christian (BS ’39, PhD HHS ’44), a professor of pharmaceutical chemistry, was conducting pioneering research in the emerging field of bionucleonics, a term that reportedly originated from then Purdue President Frederick Hovde to describe the biological application of nuclear physics. At the time, Christian was one of a handful of people in the country accomplishing meaningful work in peaceful uses of radioactive materials. 

Marching On

Marching On

The first Black woman to earn a DVM degree at Purdue University, Dr. Doris Hughes-Moore, attributes her success to the sacrifices made by her ancestors

Dr. Doris Hughes-Moore (DVM ’73) recognizes the importance of preserving and honoring history. She’s president of the board for the Wilson Bruce Evans Home Historical Society, an organization with a mission to preserve the home and promote its historical significance as part of Black American history and culture in Oberlin, Ohio. She’s also the great-great granddaughter of Wilson Bruce Evans and his wife, Sarah Jane Evans.

Demystifying the Aging Process

Demystifying the Aging Process

Identification of nuclear protein’s critical role in cell degradation could lead to prevention or even reversal of age-related diseases

Tantalizing legends of a fountain of youth spurred explorers to navigate the globe for millennia in search of the restorative waters that promised to wind back the hands of time and halt the process of aging. Recent research conducted in the Purdue University College of Veterinary Medicine and the Bindley Bioscience Center reveals the real secret lies not in myth, but in science.

As we age, our cells undergo senescence, a process where they cease dividing and enter a state of permanent growth arrest without dying off. Senescence is actually a good thing, because if cells continue to divide uncontrollably, they become tumorigenic or cancer-initiating cells. It’s when too many senescent cells build up that they cause problems.

A Gift of Love

A Gift of Love

Alumnus honors late wife by funding research for swallowing disorders

Dave Greulich (ME’67) never realized he believed in love at first sight until he met Dee.

A friend fixed the couple up on a blind date in their hometown of Louisville, Kentucky, a few weeks before Greulich left for his freshman year at Purdue. Deanna Schneider was an aspiring nurse with a gentle disposition who exhibited great empathy and care for others. Greulich was smitten. The pair continued to date while attending separate colleges and married on January 27, 1968.  

The Purdue Herbaria

The Purdue Herbaria

An insider’s look at a university collection so valuable, the professor who built it once stole it back.

The earliest herbarium—a collection of plant samples preserved for scientific study—dates to 16th-century Italy, when the Bologna physician and botanist Luca Ghini (1490–1556) sought to make plant material available to his students in winter when the plants were dead or dormant.

The specimens were flattened between two pieces of paper to remove moisture. Once dried, they were mounted on paper sheets with notations on the plant’s name, where the plant was gathered, and any distinctive features. The pages were bound into volumes to enable transport from one location to another, thus making plant material from faraway places available indefinitely.

A Milestone in Machine Learning

A Milestone in Machine Learning

Savoie research team builds largest dataset of reaction mechanisms in existence

Theoreticians have worked in tandem with experimentalists since the dawn of the scientific age. The advent of machine learning facilitated computational work on a larger scale and a faster timetable. While data about the properties of specific molecules has been available for years, predications of how those molecules would react in different environments and under various conditions remained elusive.

After developing the automated computational method YARP — Yet Another Reaction Program — two years ago, a research team led by Brett Savoie, the Charles Davidson Associate Professor of Chemical Engineering, applied YARP’s technology to build the largest dataset of reaction mechanisms in existence.

A Career of Precision and Purpose

A Career of Precision and Purpose

Oak Ridge National Laboratory’s Jeremy Busby’ 95 Developed Meticulous Mentality in K-States Nuclear Engineering Program.

On a bookshelf in Jeremy Busby’s office, tucked among scientific journals, policy manuals and bric-a-brac accumulated during his nearly 30 years as a nuclear engineer, sits his undergraduate notebook from Applied Reactors Theory I & II. Busby ’95 is now the associate lab director for the isotope science and engineering directorate at Oak Ridge National Laboratory, a federally funded research and development center in Oak Ridge, Tennessee. He took those courses with Professor Ken Shultis and Professor Richard Faw in 1992 and 1993, but the principles instilled have stayed with him throughout his distinguished career.