Stories

In Pursuit of a Non-Opioid Analgesic

In Pursuit of a Non-Opioid Analgesic

Val Watts doggedly hunts an undruggable enzyme as target for chronic pain treatment

Val Watts enjoys a tricky puzzle. The associate dean for research and professor of medicinal chemistry and molecular pharmacology built his career attempting to find solutions to problems others have deemed unsolvable. 

His latest white whale is a doozy. Watts wants to develop pain medications as strong and effective as opioids, without their addictive properties. To do so, he’s collaborating with other College of Pharmacy researchers to target the adenylyl cyclase enzyme, a signal pathway shared by opioid receptors and dopamine receptors.

Food As Medicine

Food As Medicine

Center for Health Excellence, Quality and Innovation launches Nutrition Hub at IU Health Methodist Hospital in Indy

Sufficient access to high-quality, nutritious food is necessary for overall health, but nearly 13% of U.S. households face food insecurity. A new initiative launched by the Center for Health Excellence, Quality and Innovation (CHEQI) in the College of Pharmacy aims to integrate nutrition and health care, raising awareness for the concept of food as medicine and providing patients with nutritious food tailored to their individual medical needs. 

The Nutrition Hub, which opened at IU Health Methodist Hospital in Indianapolis in November 2023, is a partnership between CHEQI, the American Heart Association and Gleaners Food Bank of Indiana, the largest hunger relief organization in the state.

Pioneering the Future of Patient Engagement

Pioneering the Future of Patient Engagement

R’Kes Starling leverages technology to expand access to clinical trials for underrepresented populations 

It all started with his mother. That’s how R’Kes Starling (BS ’02) attributes his inspiration for founding Reveles, an AI-powered patient engagement company that partners with drug sponsors and research institutions to increase awareness and expand clinical trial access to underrepresented patients. By prioritizing diversity within studies, Reveles helps to ensure marginalized communities do not miss out on life-changing care while simultaneously advancing a more equitable approach to health care. 

Purdue Nuclear Pharmacy

Purdue Nuclear Pharmacy

Oldest and largest program in the country leverages industry partnerships to advance radiopharmaceutical training in Indianapolis

In 1946, nearly 50 years after the Polish physicist and chemist Marie Curie coined the term radioactivity, Purdue University received the first shipment of radioactive materials for use in the development of medical therapy from Oak Ridge National Laboratory in Tennessee.

John E. Christian (BS ’39, PhD HHS ’44), a professor of pharmaceutical chemistry, was conducting pioneering research in the emerging field of bionucleonics, a term that reportedly originated from then Purdue President Frederick Hovde to describe the biological application of nuclear physics. At the time, Christian was one of a handful of people in the country accomplishing meaningful work in peaceful uses of radioactive materials. 

Demystifying the Aging Process

Demystifying the Aging Process

Identification of nuclear protein’s critical role in cell degradation could lead to prevention or even reversal of age-related diseases

Tantalizing legends of a fountain of youth spurred explorers to navigate the globe for millennia in search of the restorative waters that promised to wind back the hands of time and halt the process of aging. Recent research conducted in the Purdue University College of Veterinary Medicine and the Bindley Bioscience Center reveals the real secret lies not in myth, but in science.

As we age, our cells undergo senescence, a process where they cease dividing and enter a state of permanent growth arrest without dying off. Senescence is actually a good thing, because if cells continue to divide uncontrollably, they become tumorigenic or cancer-initiating cells. It’s when too many senescent cells build up that they cause problems.

A Gift of Love

A Gift of Love

Alumnus honors late wife by funding research for swallowing disorders

Dave Greulich (ME’67) never realized he believed in love at first sight until he met Dee.

A friend fixed the couple up on a blind date in their hometown of Louisville, Kentucky, a few weeks before Greulich left for his freshman year at Purdue. Deanna Schneider was an aspiring nurse with a gentle disposition who exhibited great empathy and care for others. Greulich was smitten. The pair continued to date while attending separate colleges and married on January 27, 1968.  

A Milestone in Machine Learning

A Milestone in Machine Learning

Savoie research team builds largest dataset of reaction mechanisms in existence

Theoreticians have worked in tandem with experimentalists since the dawn of the scientific age. The advent of machine learning facilitated computational work on a larger scale and a faster timetable. While data about the properties of specific molecules has been available for years, predications of how those molecules would react in different environments and under various conditions remained elusive.

After developing the automated computational method YARP — Yet Another Reaction Program — two years ago, a research team led by Brett Savoie, the Charles Davidson Associate Professor of Chemical Engineering, applied YARP’s technology to build the largest dataset of reaction mechanisms in existence.

Cracking the Code on a Universal Flu Vaccine

Cracking the Code on a Universal Flu Vaccine

Promising initial research could lead to more effective seasonal flu shots and ward against future pandemics

Dry cough. Runny nose. Sore throat. Muscle aches. These symptoms are all familiar to anyone who’s contracted the common flu, a respiratory illness that affects one billion people each year. The Centers for Disease Control and Prevention recommend most people receive yearly flu shots because the seasonal influenza virus mutates constantly, creating new strains that circulate from person-to-person leading to seasonal flu epidemics. These yearly vaccines are formulated to protect against the specific virus strains expected to spread and cause illness during that flu season, typically October through May.